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Ⅸ.Fine
Chemicals and Biochemical Engineering
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DEVELOPMENT
AND APPLICATION OF TECHNOLOGY FOR PRODUCING METHYL
ETHYL KETONE
Lü
Zhihui Qiao Kai Su Jie Ma Hao Zhai Qingtong
Abstract
The
technology for producing methyl ethyl ketone (MEK)
from butylene by hydration and dehydrogenation has
been developed successfully. The processes of the
technology include the process of sec-butanol (SBA)
through n-butylene hydration, and the process of MEK
by SBA dehydrogenation. The development and
application of the appropriate catalysts are also
included. This technology has its special originality.
The thermo-stable resin catalyst and SBA
dehydrogenation catalyst have good performance. Under
the reaction conditions, the conversion of n-butylene
was higher than 8%, and the selectivity of sec-butanol
was over 98%. The conversion of sec-butanol was more
than 80%, and the selectivity of MEK was over 96%. The
process for producing MEK has been commercialized in a
unit with a capacity of 20,000 tons/a.
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STUDY
OF SYNTHESIZING METHYL ISOBUTYL KETONE THROUGH
SINGLE-STAGE CONVERSION OF ACETONE
Ai
Fubin Lü Zhihui
Song Lizhi Wang Haibo
Wang Shunnong Chen Ming Wang Chunmei
Abstract
This
paper presents some experimental results, including
synthesizing methyl isobutyl ketone in a 300ml-reactor
using acetone and hydrogen as raw materials, and
determining the optimal operating conditions by
observing the influence of reaction phase, feed,
temperature, pressure, LHSV and H2/acetone
ratio. The results of the 1300-hour test showed that
the catalyst exhibited better activity and stability.
The results on conversion and selectivity obtained
from the bench tests were the same as that obtained
from the pilot plant. This technology was first
commercialized successfully in 1996.
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DEVELOPMENT
OF A NOVEL CATALYST FOR SYNTHESIS OF DIPHENYLAMINE
AND ITS APPLICATION
Song
Lizhi Lü
Zhihui AI Fubin Xu Liang Ge Zhixin
Wang Haibo Chen Ming Wang Shunnong
Abstract
The
effect of βzeolites with
various Si/Al atomic ratios and addition of promotes
(metals) on catalytic performance has been studied.
The experimental results showed that by adding
promotes, the modified βzeolite
has special catalytic activity, stability and
catalytic performance. Without corrosion, the newly
developed catalyst FD-20 showed good activity and
stability, as well as good regeneration property. The
catalyst has been scaled-up, and exhibited good
repetition. Its performance was better than similar
catalysts abroad. The kinetic equation of the
reactions may be expressed as follows: r=[CBA/(CBA
+KDCD/ KBA)]2K.
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SYNTHESIS
AND APPLICATION OF DNW THERMO-STABLE ION EXCHANGE
RESIN CATALYST
Huo
Wenzhou Yu Diming Guo Cangxin Gou Liankei Zou
Dengfeng
Abstract
This
paper presents a process for synthesizing DNW
thermo-stabile ion exchange resin catalyst by using
styrene and di-vinyl benzene as raw materials. The
synthesis procedure included polymerizing, extracting,
bromizating, sulphonating and stabilizing of the
active groups. The physical and molecular structure，the
relation between molecular structure and
thermo-stability, mutual influence between various
introducing-ratios of electron-attacting groups and
the sulphonating groups were also studied by using
2400 type N2 physical adsorption apparatus,
13C NMR and static/dynamic thermo-stability
testing methods. Furthermore, the conditions of
synthesizing process were optimized. The activity and
thermal stability of the prepared DNW resin catalyst
has attained or even surpassed advanced world level of
the same type of catalyst. The catalyst was used in
the butylene hydration equipment with a capacity of
12000t/a in HEILONGJIANG petrochemicals factory, the
initial temperature was 135℃,
pressure 6.0MPa, alkene space velocity 1.5 h-1,
water/alkene molar ratio 1.0. After over 9,000 hours
continually operating, the yield of 2-butanol for
single pass was over 6.0%, the selectivity of
2-butanol was over 99%. The catalyst was also used in
the butylenes hydration plant with a capacity of
20000t/a in QILU company, the reaction temperature was
130℃; pressure 6.0MPa;
alkene space velocity 1.0h-1 and
water/alkene molar ratio 1.5. After more than 7,000
hours continually operating, the butylene conversion
was higher than 6.5%, and the selectivity of 2-butanol
was over 99%.
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TECHNIQUE
OF SYNTHESIZING ISOPROPYL ALCOHOL THROUGH PROPYLENE
HYDRATION
Ma
Hao Lu ZhiHui Zhang Shumei Zhai Qingtong
Abstract
The
present situation at home country and abroad on
synthesizing isopropyl alcohol through propylene
direct hydration, as well as production and
consumption of isopropyl alcohol are briefly reviewed
in this paper. It is centered on the production
technology of isopropyl alcohol developed by FRIPP,
SINOPEC, including synthesizing isopropyl alcohol
through propylene direct hydration and the preparation
and application of dedicated resin catalyst for
hydration. The results showed that the production
technology of isopropyl alcohol developed by FRIPP is
superior to similar technology abroad with its
proprietary intellectual property and unique
innovation.
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STUDY
OF THE CANDIDA TROPICALIS FOR PRODUCING LONG-CHAIN
ICARBOXYLIC ACID
Li
Shulan Tong Mingyou Liu Shuchen
Abstract
In
this paper, candida tropicalis were studied for
producing long-chain acid. A series of good bacterium
was obtained through repeated mutagen and selection.
The effect of changing carbon source and culture
conditions on the growth of the bacterium was
investigated, and the way of absorbing alkane by
bacterium, and the morphology of bacterium during
fermentation were also observed.
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PRODUCTION
OF 1,13-TRIDECANEDIOIC ACID
BY
FERMENTATION
Liu
Shuchen Li Shulan Zhang Jiangang
Yang Dong
Wang Lingmin Fang Xiangchen Han Chongren
Abstract
A
mutant of Candida tropicalis SP-UV-56, which
can hardly assimilates n-alkane as carbon source, was
obtained from its parent bacterium SP-1 through
repeated mutagenesis by radiation of ultraviolet rays.
For the production of 1,13-tridecanedioic acid (DCA13)
by the mutant in flasks, DCA13 achieved a
mean concentration of 72 g/L after 5 d incubation,
about 1.25 times higher than bacterium SP-1. The yield
of DCA13 reached 153 g/L after 144 h
incubation by the addition of acetate in a 13.7 L
bioreactor, with an increase of 29.7% compared to the
fermentation without addition of acetate.
DCA13 production
in a pilot plant with 20 m3 stirred-tank
reactors was also studied. The stirred- tank reactors
were designed by a rule of geometric similarity and
the equivalent power-per-unit-volume. Effect of two
types of impellers, such as plat blade disc
turbine-installed and arrow-like plat disc
turbine-installed impeller on the yield of DCA13
was also investigated. In comparison to the
experiments using arrow-like plat disc
turbine-installed impeller，a
mean concentration of DCA13 obtained from
three independent runs after 144 h incubation achieved
156.5 g/L, with an increase of 15.5%, but 15.6% higher
in power consumption. The highest yield reached 172
g/L.
The
white powdered product was obtained by
recrystallization using an organic solvent extraction,
the purity is more than 97m%, while the content of
total precipitated dicarboxylic acids is over 99%.
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STUDY
ON SYNTHESIS TECHNOLOGY OF MUSK-T
Wang
Chonghui Zhang Yanli Song Xijun
Abstract
Musk-T
(ethylene brassylate), an artificial perfume with
macro ring diester, has found wide application in
blending various high-grade flavors of goods, such as
cosmetics and perfume for daily use. In the course of
development, highly effective depolymerizing catalyst
and polymerization retarder were developed, and the
process of synthesis and purification was optimized.
Based on the study of enlargement regularity, the
technical problem in enlargement was solved, and the
designs of process, mechanism and systematic automatic
control were all accomplished. The control of vacuum
degree in decompressing was solved, and the ways of
agitation and heating were also improved. The
synthesis of Musk-T has successfully commercialized in
a unit with a capacity of 50t/a, having yield of the
product up to 87.1m% and purity of the product over
97.0%. It indicated that the commercial results had
good repetition of the laboratory tests, and the
product was pure in sweet smell and excellent in
quality.
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SELECTION
OF STRAIN FOR MICRPBIOLOGICAL DESULFURIZATION AND
STUDY ON ITS BIO-DESULFURIZATION CHARACTERISTICS
Tong
Mingyou Zhang Quan Li Shulan
Abstract
A
piece of the strain, called FS-DS1(Rhodococcus sp),
separated from soil, showed concentrated ability on
transforming dibenzothiophene (DBT) into water-soluble
2-hydro-benzophene (2-HBP). By using this strain,
organic sulfur in diesel was removed as to reduce the
sulfur content of the product without destroying the
carbon-carbon bond. In this paper, the way of the
strain selection, the study of conditions for the
strain growth, and the preliminary results for removal
of DBT from diesel are introduced.
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REGULATION
OF INTRACELLULAR PH OF CANDIDA TROPICALIS
TO METABOLIC ACTIVITY FOR PRODUCING DICARBOXYLIC
ACID
Liu
Shuchen Fang Xiangchen
Abstract
The
regulation of intracellular pH (pHi) to
metabolic activity of Candida tropicalis
SP-UV-56, during the production of α, ω-tridecanedioic
acid, was investigated. The pHi ovalue of
the Candida tropicalis was measured by using
5(6)-carboxyfluorescein diacetate (cFDA) as a
pH-sensitive fluorescent probe. Suitable loading
conditions of cFDA into the cells were determined.
Fermentation with n-tridecane substrate to produce α,
ω-tridecanedioic acid was carried out in a 5-L
bioreactor. The fermentation process included growth
period of bacterium and production of the acid. In
growth period of bacterium, the measured pHi
varied from 5.60 to 6.0 when the pH of medium was 6.0.
The specific growth rates of cells in growth period,
specific consumption rate of sucrose, production rate
of CO2, and consumption rate of O2 were
correlated with pHi. The expression of
cytochrome monooxygenase (P450) in the growth period,
was inhibited. During the first 6-h of the acid
production, P450 activity was induced rapidly
corresponding with higher pHi. A much
higher level of P450 activity was observed at pHi
of 6.50±0.10 during
fermenting, but P450 activity was markedly decreased
when pHi was below 6.2. These results
indicated that the metabolic activity of C.
tropicalis is sensitive to the variations in pHi.
Thus, both tridecanedioic acid productivity and P450
activity are sensitive to pHi or pH
gradients across cell membrane.
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